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Tissue Fluid

Exam code: 5090
Written by: Ashika|Reviewed by: Caroline Carroll|Updated 2 July 2026

Tissue Fluid

Tissue Fluid

  • Plasma is a straw-coloured liquid that constitutes around 55% of the blood

  • Plasma is largely composed of water (95%) and because water is a good solvent, many substances can dissolve in it, allowing them to be transported around the body

  • As blood passes through capillaries, some plasma is forced out (under pressure) through gaps in the walls of the capillary to surround the cells of the body

    • This results in the formation of tissue fluid

  • The composition of plasma and tissue fluid are virtually the same, although tissue fluid contains far fewer proteins

    • Proteins are too large to fit through gaps in the capillary walls and so remain in the blood

  • Tissue fluid bathes almost all the cells of the body outside of the circulatory system

  • The exchange of substances between cells and the blood occurs via the tissue fluid

    • For example, carbon dioxide produced in aerobic respiration will leave a cell, dissolve into the tissue fluid surrounding it, and then diffuse into the capillary

    • This is how all substances are exchanged between cells and their surroundings in large, multicellular organisms

Formation of Tissue Fluid Diagram

tissue fluid formation bathing cells

Formation of tissue fluid